Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia

Background: Acute lymphoblastic leukemia (ALL) results from genetic alterations in a single lymphoid progenitor cell. Expression of ROR1 is reported to be increased in ALL and mantle cell lymphoma. In this study the expression of ROR1 was assessed in newly diagnosed patients with ALL.  Methods: This study was carried out on 40 patients with newly diagnosed ALL and healthy individuals as control group. Quantification of ROR1 mRNA expression by Real Time quantitative PCR was performed. The expressions of ROR gene in patients were compared with the control group. Results: ROR1 mRNA expression (Fold Changes) in patients with ALL was 2.85±3.51. ROR1 mRNA expression in patients with ALL was significantly higher than normal individuals (P<0.001). There was not any relationship between the expression of ROR1 and cytogenetic abnormalities. Conclusion: We assessed ROR1 gene expression on mRNA of 40 ALL patients at diagnosis. The results showed that ROR1 expression had significant increase in ALL patients compared with healthy controls.